Excess Type I Interferon Signaling in the Mouse Seminiferous Tubules Leads to Germ Cell Loss and Sterility

Type I (α and β) interferons (IFNs) elicit antiproliferative and antiviral activities via the surface receptor IFNAR. Serendipitous observations in transgenic mice in 1988 strongly suggested that IFNα/β overexpression in the testis disrupts spermatogenesis. Here, we compare a new mouse strain transg...

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Detalhes bibliográficos
Main Authors: Satie, Anne-Pascale, Mazaud-Guittot, Severine, Seif, Isabelle, Mahé, Dominique, He, Zhiguo, Jouve, Guilhem, Jégou, Bernard, Dejucq-Rainsford, Nathalie
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3123094/
https://ncbi.nlm.nih.gov/pubmed/21515676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.229120
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