Bortezomib induction of C/EBPβ mediates Epstein-Barr virus lytic activation in Burkitt lymphoma

Epstein-Barr virus (EBV) is associated with a variety of lymphoid malignancies. Bortezomib activates EBV lytic gene expression. Bortezomib, a proteasome inhibitor, leads to increased levels of CCAAT/enhancer-binding proteinβ (C/EBPβ) in a variety of tumor cell lines. C/EBPβ activates the promoter of...

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Autores principales: Shirley, Courtney M., Chen, Jianmeng, Shamay, Meir, Li, Huili, Zahnow, Cynthia A., Hayward, S. Diane, Ambinder, Richard F.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2011
Materias:
Lymphoid Neoplasia
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3122948/
https://ncbi.nlm.nih.gov/pubmed/21447826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-01-332379
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