Intranasal Vaccination with the Recombinant Listeria monocytogenes ΔactA prfA* Mutant Elicits Robust Systemic and Pulmonary Cellular Responses and Secretory Mucosal IgA

We previously showed that recombinant (r) Listeria monocytogenes carrying ΔactA and a selected prfA* mutation (r-Listeria ΔactA prfA*) secreted >100-fold more immunogen in broth culture than wild-type r-Listeria or r-Listeria ΔactA and elicited much greater cellular and humoral immune responses t...

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Bibliografske podrobnosti
Main Authors: Qiu, Jin, Yan, Lin, Chen, Jianbo, Chen, Crystal Y., Shen, Ling, Letvin, Norman L., Haynes, Barton F., Freitag, Nancy, Rong, Lijun, Frencher, James T., Huang, Dan, Wang, Xunming, Chen, Zheng W.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2011
Teme:
Vaccine Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3122559/
https://ncbi.nlm.nih.gov/pubmed/21270282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00254-10
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