Modest but Variable Effect of Rifampin on Steady-State Plasma Pharmacokinetics of Efavirenz in Healthy African-American and Caucasian Volunteers

Efavirenz-based antiretroviral regimen is preferred during rifampin-containing tuberculosis therapy. However, current pharmacokinetic data are insufficient to guide optimized concurrent dosing. This study aimed to better characterize the effects of rifampin on efavirenz pharmacokinetics. Subjects we...

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Autores principales: Kwara, Awewura, Tashima, Karen T., Dumond, Julie B., Poethke, Pamela, Kurpewski, Jaclyn, Kashuba, Angela D. M., Court, Michael H., Greenblatt, David J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2011
Materias:
Antiviral Agents
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3122441/
https://ncbi.nlm.nih.gov/pubmed/21518840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00980-10
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