Distinct Roles of Transforming Growth Factor-β-activated Kinase 1 (TAK1)-c-Rel and Interferon Regulatory Factor 4 (IRF4) Pathways in Human T Cell Lymphotropic Virus 1-transformed T helper 17 Cells Producing Interleukin-9

Investigation of helper T cell markers in HTLV-1-transformed cell lines demonstrated that HuT-102 has an IL-9-producing Th17 phenotype. We confirmed the vital role of retinoic acid-related orphan receptor C, a Th17 transcription factor, in the expression of IL-17. Interferon regulatory factor 4 (IRF...

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Détails bibliographiques
Auteurs principaux: Refaat, Alaa, Zhou, Yue, Suzuki, Shunsuke, Takasaki, Ichiro, Koizumi, Keiichi, Yamaoka, Shoji, Tabuchi, Yoshiaki, Saiki, Ikuo, Sakurai, Hiroaki
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2011
Sujets:
Molecular Bases of Disease
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3122170/
https://ncbi.nlm.nih.gov/pubmed/21498517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.200907
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