MicroRNA-21 targets peroxisome proliferators-activated receptor-α in an autoregulatory loop to modulate flow-induced endothelial inflammation

Adhesion of circulating monocytes to vascular endothelial cells (ECs) is a critical event leading to vascular inflammation and, hence, development of atherosclerosis. MicroRNAs (miRs) are a class of endogenous, highly conserved, noncoding small RNAs that play important roles in regulating gene expre...

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Bibliographische Detailangaben
Hauptverfasser: Zhou, Jing, Wang, Kuei-Chun, Wu, Wei, Subramaniam, Shankar, Shyy, John Y.-J., Chiu, Jeng-Jiann, Li, Julie Y.-S., Chien, Shu
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2011
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3121870/
https://ncbi.nlm.nih.gov/pubmed/21636785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1107052108
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