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Loss of Bardet–Biedl syndrome protein-8 (BBS8) perturbs olfactory function, protein localization, and axon targeting

Bardet–Biedl syndrome (BBS) is a pleiotropic, heterogeneous human disease whose etiology lies primarily in dysfunctional basal bodies and/or cilia. Both BBS patients and several BBS mouse models exhibit impaired olfactory function. To explore the nature of olfactory defects in BBS, a genetic ablatio...

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Detalhes bibliográficos
Main Authors: Tadenev, Abigail L. D., Kulaga, Heather M., May-Simera, Helen L., Kelley, Matthew W., Katsanis, Nicholas, Reed, Randall R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3121838/
https://ncbi.nlm.nih.gov/pubmed/21646512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1016531108
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