Metformin therapy in a hyperandrogenic anovulatory mutant murine model with polycystic ovarian syndrome characteristics improves oocyte maturity during superovulation

BACKGROUND: Metformin, an oral biguanide traditionally used for the treatment of type 2 diabetes, is widely used for the management of polycystic ovary syndrome (PCOS)-related anovulation. Because of the significant prevalence of insulin resistance and glucose intolerance in PCOS patients, and their...

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Detalhes bibliográficos
Main Authors: Sabatini, Mary E, Guo, Lankai, Lynch, Maureen P, Doyle, Joseph O, Lee, HoJoon, Rueda, Bo R, Styer, Aaron K
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3121715/
https://ncbi.nlm.nih.gov/pubmed/21605417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1757-2215-4-8
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