Mutation of the elongin C binding domain of human respiratory syncytial virus non-structural protein 1 (NS1) results in degradation of NS1 and attenuation of the virus

BACKGROUND: Human respiratory syncytial virus (RSV) is an important cause of lower respiratory tract disease in the paediatic population, immunocompromised individuals and the elderly worldwide. However, despite global efforts over the past several decades there are no commercially available vaccine...

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Detalhes bibliográficos
Main Authors: Straub, Claire P, Lau, Wei-Har, Preston, Faith M, Headlam, Madeleine J, Gorman, Jeffery J, Collins, Peter L, Spann, Kirsten M
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3121706/
https://ncbi.nlm.nih.gov/pubmed/21600055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-422X-8-252
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