A Novel Mode of Protein Kinase Inhibition Exploiting Hydrophobic Motifs of Autoinhibited Kinases: DISCOVERY OF ATP-INDEPENDENT INHIBITORS OF FIBROBLAST GROWTH FACTOR RECEPTOR

Protein kinase inhibitors with enhanced selectivity can be designed by optimizing binding interactions with less conserved inactive conformations because such inhibitors will be less likely to compete with ATP for binding and therefore may be less impacted by high intracellular concentrations of ATP...

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Autores principales: Eathiraj, Sudharshan, Palma, Rocio, Hirschi, Marscha, Volckova, Erika, Nakuci, Enkeleda, Castro, Jennifer, Chen, Chang-Rung, Chan, Thomas C. K., France, Dennis S., Ashwell, Mark A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Protein Structure and Folding
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3121527/
https://ncbi.nlm.nih.gov/pubmed/21454610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.213736
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