NMR Solution Structure of Human Vaccinia-related Kinase 1 (VRK1) Reveals the C-terminal Tail Essential for Its Structural Stability and Autocatalytic Activity

Vaccinia-related kinase 1 (VRK1) is one of the mitotic kinases that play important roles in cell cycle, nuclear condensation, and transcription regulation. Kinase domain structures of two other VRK family members (VRK2 and VRK3) have been determined previously. However, the structure of VRK1, the mo...

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Detalhes bibliográficos
Main Authors: Shin, Joon, Chakraborty, Goutam, Bharatham, Nagakumar, Kang, CongBao, Tochio, Naoya, Koshiba, Seizo, Kigawa, Takanori, Kim, Wanil, Kim, Kyong-Tai, Yoon, Ho Sup
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3121357/
https://ncbi.nlm.nih.gov/pubmed/21543316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.200162
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