The p53 Tumor Suppressor Is Stabilized by Inhibitor of Growth 1 (ING1) by Blocking Polyubiquitination

The INhibitor of Growth tumor suppressors (ING1-ING5) affect aging, apoptosis, DNA repair and tumorigenesis. Plant homeodomains (PHD) of ING proteins bind histones in a methylation-sensitive manner to regulate chromatin structure. ING1 and ING2 contain a polybasic region (PBR) adjacent to their PHDs...

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Main Authors: Thalappilly, Subhash, Feng, Xiaolan, Pastyryeva, Svitlana, Suzuki, Keiko, Muruve, Daniel, Larocque, Daniel, Richard, Stephane, Truss, Matthias, von Deimling, Andreas, Riabowol, Karl, Tallen, Gesche
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2011
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3120833/
https://ncbi.nlm.nih.gov/pubmed/21731648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0021065
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