HMGB1 Attenuates Cardiac Remodelling in the Failing Heart via Enhanced Cardiac Regeneration and miR-206-Mediated Inhibition of TIMP-3

AIMS: HMGB1 injection into the mouse heart, acutely after myocardial infarction (MI), improves left ventricular (LV) function and prevents remodeling. Here, we examined the effect of HMGB1 in chronically failing hearts. METHODS AND RESULTS: Adult C57 BL16 female mice underwent coronary artery ligati...

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Hlavní autoři: Limana, Federica, Esposito, Grazia, D'Arcangelo, Daniela, Di Carlo, Anna, Romani, Sveva, Melillo, Guido, Mangoni, Antonella, Bertolami, Chiara, Pompilio, Giulio, Germani, Antonia, Capogrossi, Maurizio C.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2011
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3120764/
https://ncbi.nlm.nih.gov/pubmed/21731608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0019845
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