Serum Amyloid A (SAA) Activates the NLRP3 Inflammasome and Promotes T(H)17 Allergic Asthma in Mice

Interleukin (IL)-1β is a cytokine critical to several inflammatory diseases in which pathogenic T(H)17 responses are implicated. Activation of the NLRP3 inflammasome by microbial and environmental stimuli can enable the caspase-1 dependent processing and secretion of IL-1β. The acute phase protein s...

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Bibliographische Detailangaben
Hauptverfasser: Ather, Jennifer L., Ckless, Karina, Martin, Rebecca, Foley, Kathryn L., Suratt, Benjamin T., Boyson, Jonathan E., Fitzgerald, Katherine A., Flavell, Richard A., Eisenbarth, Stephanie C., Poynter, Matthew E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3119761/
https://ncbi.nlm.nih.gov/pubmed/21622869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1100500
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