MHC class II epitope nesting modulates dendritic cell function and improves generation of antigen-specific CD4 helper T cells

CD4 T helper cells are critical to the development of coordinated immune responses to infections and tumors. T helper cells are activated through interactions of the TCR with MHC class II complexed with peptide. T cell activation is dependent on the density of MHC peptide complexes as well as the du...

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Main Authors: Erskine, Courtney L., Krco, Christopher J., Hedin, Karen E., Borson, Nancy D., Kalli, Kimberly R., Behrens, Marshall D., Heman-Ackah, Sabrina M., von Hofe, Eric, Wettstein, Peter J., Mohamadzadeh, Mansour, Knutson, Keith L.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3119756/
https://ncbi.nlm.nih.gov/pubmed/21613617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1100658
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