Potential use of oxygen as a metabolic biosensor in combination with T2*-weighted MRI to define the ischemic penumbra

We describe a novel magnetic resonance imaging technique for detecting metabolism indirectly through changes in oxyhemoglobin:deoxyhemoglobin ratios and T2* signal change during ‘oxygen challenge’ (OC, 5 mins 100% O(2)). During OC, T2* increase reflects O(2) binding to deoxyhemoglobin, which is form...

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Detalhes bibliográficos
Main Authors: Santosh, Celestine, Brennan, David, McCabe, Christopher, Macrae, I Mhairi, Holmes, William M, Graham, David I, Gallagher, Lindsay, Condon, Barrie, Hadley, Donald M, Muir, Keith W, Gsell, Willy
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3119432/
https://ncbi.nlm.nih.gov/pubmed/18545262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2008.56
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