Successful treatment of metastatic melanoma by adoptive transfer of blood-derived polyclonal tumor-specific CD4+ and CD8+ T cells in combination with low-dose interferon-alpha

A phase I/II study was conducted to test the feasibility and safety of the adoptive transfer of tumor-reactive T cells and daily injections of interferon-alpha (IFNα) in metastatic melanoma patients with progressive disease. Autologous melanoma cell lines were established to generate tumor-specific...

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Autors principals: Verdegaal, Els M. E., Visser, Marten, Ramwadhdoebé, Tamara H., van der Minne, Caroline E., van Steijn, Jeanne A. Q. M. J., Kapiteijn, Ellen, Haanen, John B. A. G., van der Burg, Sjoerd H., Nortier, Johan W. R., Osanto, Susanne
Format: Artigo
Idioma:Inglês
Publicat: Springer-Verlag 2011
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3119331/
https://ncbi.nlm.nih.gov/pubmed/21431917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-011-1004-8
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