The Tubulin-Binding Agent Combretastatin A-4-Phosphate Arrests Endothelial Cells in Mitosis and Induces Mitotic Cell Death

The tubulin-binding agent combretastatin A-4-phosphate (CA-4-P), rapidly disrupts the vascular network of tumors leading to secondary tumor cell death. In vitro, CA-4-P destabilizes microtubules and causes endothelial cell death. In this study we analyze the mechanisms by which CA-4-P induces the de...

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Main Authors: Kanthou, Chryso, Greco, Olga, Stratford, Anna, Cook, Ian, Knight, Richard, Benzakour, Omar, Tozer, Gillian
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Investigative Pathology 2004
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Regular Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3118836/
https://ncbi.nlm.nih.gov/pubmed/15466404
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