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Cyclization of a Cellular Dipentaenone by Streptomyces coelicolor Cytochrome P450 154A1 without Oxidation/Reduction

We report a comprehensive genetic, metabolomic, and biochemical study on the catalytic properties of Streptomyces coelicolor cytochrome P450 (P450) 154A1, known to have a unique heme orientation in its crystal structure. Deletion of the P450 154A1 gene compromised the long-term stability of the bact...

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Sonraí Bibleagrafaíochta
Main Authors: Cheng, Qian, Lamb, David C., Kelly, Steven L., Lei, Li, Guengerich, F. Peter
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2010
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3118511/
https://ncbi.nlm.nih.gov/pubmed/20979426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja107801v
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