Suppression of ras-mediated transformation and inhibition of tumor growth and angiogenesis by anthrax lethal factor, a proteolytic inhibitor of multiple MEK pathways

Lethal factor is a protease, one component of Bacillus anthracis exotoxin, which cleaves many of the mitogen-activated protein kinase kinases (MEKs). Given the importance of MEK signaling in tumorigenesis, we assessed the effects of anthrax lethal toxin (LeTx) on tumor cells. LeTx was very effective...

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Publicat a:	Proc Natl Acad Sci U S A
Autors principals:	Duesbery, N. S., Resau, J., Webb, C. P., Koochekpour, S., Koo, H.-M., Leppla, S. H., Vande Woude, G. F.
Format:	Artigo
Idioma:	Inglês
Publicat:	National Academy of Sciences 2001
Matèries:	Biological Sciences
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC31184/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11259649/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.061031898
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