Onconase Mediated NFKβ Down-Regulation in Malignant Pleural Mesothelioma

PURPOSE: Treatment of malignant pleural mesothelioma (MPM) with Ranpirnase (Onconase) results in disruption of protein translation and cell apoptosis. We hypothesize that Onconase acts via down regulation of nuclear factor kappa B (NFKβ) by specific microRNAs (miRNA) and that interference of this pa...

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Main Authors: Goparaju, Chandra M., Blasberg, Justin D., Volinia, Stefano, Palatini, Jeff, Ivanov, Sergey, Donington, Jessica S., Croce, Carlo, Carbone, Michele, Yang, Haining, Pass, Harvey I.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3118086/
https://ncbi.nlm.nih.gov/pubmed/21317924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.643
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