Eed/Sox2 regulatory loop controls ES cell self-renewal through histone methylation and acetylation

Transcription factors and epigenetic modulators are involved in the maintenance of self-renewal in embryonic stem (ES) cells. Here, we demonstrate the existence of a regulatory loop in ES cells between Sox2, an indispensable transcription factor for self-renewal, and embryonic ectoderm development (...

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Detalhes bibliográficos
Main Authors: Ura, Hiroki, Murakami, Kazuhiro, Akagi, Tadayuki, Kinoshita, Keita, Yamaguchi, Shukuro, Masui, Shinji, Niwa, Hitoshi, Koide, Hiroshi, Yokota, Takashi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3117647/
https://ncbi.nlm.nih.gov/pubmed/21540835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.126
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