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Germline KRAS Mutations Cause Aberrant Biochemical and Physical Properties Leading to Developmental Disorders

The KRAS gene is the most common locus for somatic gain-of-function mutations in human cancer. Germline KRAS mutations were shown recently to be associated with developmental disorders, including Noonan syndrome (NS), cardio-facio-cutaneous syndrome (CFCS), and Costello syndrome (CS). The molecular...

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Detalhes bibliográficos
Main Authors: Gremer, Lothar, Merbitz-Zahradnik, Torsten, Dvorsky, Radovan, Cirstea, Ion C., Kratz, Christian Peter, Zenker, Martin, Wittinghofer, Alfred, Ahmadian, Mohammad Reza
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3117284/
https://ncbi.nlm.nih.gov/pubmed/20949621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/humu.21377
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