Muscle-specific mutations accumulate with aging in critical human mtDNA control sites for replication

The recently discovered aging-dependent large accumulation of point mutations in the human fibroblast mtDNA control region raised the question of their occurrence in postmitotic tissues. In the present work, analysis of biopsied or autopsied human skeletal muscle revealed the absence or only minimal...

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Detalhes bibliográficos
Main Authors: Wang, Yan, Michikawa, Yuichi, Mallidis, Con, Bai, Yan, Woodhouse, Linda, Yarasheski, Kevin E., Miller, Carol A., Askanas, Valerie, Engel, W. King, Bhasin, Shalender, Attardi, Giuseppe
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2001
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC31172/
https://ncbi.nlm.nih.gov/pubmed/11274426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.061013598
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