Molecular Dynamics Simulations of DNA/PEI Complexes: Effect of PEI Branching and Protonation State

Complexes formed by DNA and polyethylenimine (PEI) are of great research interest because of their application in gene therapy. In this work, we carried out all-atom molecular dynamics simulations to study eight types of DNA/PEI complexes, each of which was formed by one DNA duplex d(CGCGAATTCGCG)(2...

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Hlavní autoři: Sun, Chongbo, Tang, Tian, Uludağ, Hasan, Cuervo, Javier E.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Biophysical Society 2011
Témata:
Nucleic Acid
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3117188/
https://ncbi.nlm.nih.gov/pubmed/21641321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2011.04.045
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