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Clinical implications of UGT1A1*28 genotype testing in colorectal cancer patients
BACKGROUND: Metastatic colorectal cancer is frequently treated with irinotecan, a topoisomerase-I inhibitor. The UGT1A1 gene encodes for an enzyme that metabolizes irinotecan and its genetic variants were shown to be associated with increased drug toxicity. We evaluated clinical outcomes associated...
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| Auteurs principaux: | , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3117027/ https://ncbi.nlm.nih.gov/pubmed/21287524 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.25735 |
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