Quinpramine Ameliorates Rat Experimental Autoimmune Neuritis and Redistributes MHC Class II Molecules

Activation of inflammatory cells is central to the pathogenesis of autoimmune demyelinating diseases of the peripheral nervous system. The novel chimeric compound quinpramine—generated from imipramine and quinacrine—redistributes cholesterol rich membrane domains to intracellular compartments. We st...

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Main Authors: Meyer zu Hörste, Gerd, Mausberg, Anne K., Müller, Johanna I., Lehmann, Helmar C., Löber, Stefan, Gmeiner, Peter, Hartung, Hans-Peter, Stüve, Olaf, Korth, Carsten, Kieseier, Bernd C.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3116892/
https://ncbi.nlm.nih.gov/pubmed/21698177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0021223
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