Selective serotonin 5-HT(2C) receptor activation suppresses the reinforcing efficacy of cocaine and sucrose but differentially affects the incentive-salience value of cocaine- vs. sucrose-associated cues

Serotonin (5-HT) controls affective and motivational aspects of palatable food and drug reward and the 5-HT(2C) receptor (5-HT(2C)R) has emerged as a key regulator in this regard. We have evaluated the efficacy of a selective 5-HT(2C)R agonist, WAY 163909, in cocaine and sucrose self-administration...

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Huvudupphovsmän: Cunningham, Kathryn A., Fox, Robert G., Anastasio, Noelle C., Bubar, Marcy J., Stutz, Sonja J., Moeller, F. Gerard, Gilbertson, Scott R., Rosenzweig-Lipson, Sharon
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2011
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3115535/
https://ncbi.nlm.nih.gov/pubmed/21575646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2011.04.034
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