Leukemic Mutations in the Methylation-Associated Genes DNMT3A and IDH2 are Rare Events in Pediatric AML: A Report from the Children’s Oncology Group

BACKGROUND: Mutations in the DNMT3A, TET2, IDH1, and IDH2 genes carry prognostic significance and occur frequently in adult AML. Leukemic mutations in all four genes have recently been implicated in aberrant DNA methylation, a hallmark of neoplasia. We previously reported that IDH1 mutations were ab...

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Détails bibliographiques
Auteurs principaux: Ho, Phoenix A., Kutny, Matthew A., Alonzo, Todd A., Gerbing, Robert B., Joaquin, Jason, Raimondi, Susana C., Gamis, Alan S., Meshinchi, Soheil
Format: Artigo
Langue:Inglês
Publié: 2011
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3115394/
https://ncbi.nlm.nih.gov/pubmed/21504050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.23179
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