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A GAG trinucleotide-repeat polymorphism in the gene for glutathione biosynthetic enzyme, GCLC, affects gene expression through translation

A guanine-adenine-guanine (GAG) repeat polymorphism with 5 different alleles (4, 7, 8, 9, and 10 repeats) in the 5′ untranslated region (UTR) of GCLC has been associated with altered GCL activity and glutathione (GSH) levels. We investigated whether this polymorphism affects either transcription or...

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Detalhes bibliográficos
Main Authors: Nichenametla, Sailendra N., Lazarus, Philip, Richie, John P.
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3114536/
https://ncbi.nlm.nih.gov/pubmed/21444626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.10-174011
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