Targeting of α(v)-Integrins in Stem/Progenitor Cells and Supportive Microenvironment Impairs Bone Metastasis in Human Prostate Cancer

Acquisition of an invasive phenotype by cancer cells is a requirement for bone metastasis. Transformed epithelial cells can switch to a motile, mesenchymal phenotype by epithelial-mesenchymal transition (EMT). Recently, it has been shown that EMT is functionally linked to prostate cancer stem cells,...

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Autors principals: van der Horst, Geertje, van den Hoogen, Christel, Buijs, Jeroen T, Cheung, Henry, Bloys, Henny, Pelger, Rob CM, Lorenzon, Giocondo, Heckmann, Bertrand, Feyen, Jean, Pujuguet, Philippe, Blanque, Roland, Clément-Lacroix, Philippe, van der Pluijm, Gabri
Format: Artigo
Idioma:Inglês
Publicat: Neoplasia Press Inc. 2011
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3114245/
https://ncbi.nlm.nih.gov/pubmed/21677875
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