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Amphipols stabilize the Chlamydia major outer membrane protein and enhance its protective ability as a vaccine
The native major outer membrane protein (nMOMP) from Chlamydia was purified in its trimeric form using the zwitterionic detergent Z3-14. In aliquots from this preparation, Z3-14 was exchanged for amphipol (APol) A8-35. CD analysis showed that trapping with A8-35 improved the thermostability of nMOMP...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3114171/ https://ncbi.nlm.nih.gov/pubmed/21550371 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2011.04.065 |
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