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PKC-Mediated Secretion of Death Factors in LNCaP Prostate Cancer Cells Is Regulated by Androgens

Activation of PKCδ in androgen-dependent LNCaP prostate cancer cells leads to apoptosis via the activation of p38 MAPK and JNK cascades. We have recently shown that treatment of LNCaP cells with phorbol 12-myristate 13-acetate (PMA) leads to a PKCδ-mediated autocrine release of death factors, includ...

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Sonraí Bibleagrafaíochta
Main Authors: Xiao, Liqing, Gonzalez-Guerrico, Anatilde, Kazanietz, Marcelo G.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2009
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3113613/
https://ncbi.nlm.nih.gov/pubmed/18756441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mc.20476
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