DNA hypomethylation caused by Lsh deletion promotes erythroleukemia development

Hematopoietic malignancies are frequently associated with DNA hypomethylation but the molecular mechanisms involved in tumor formation remain poorly understood. Here we report that mice lacking Lsh develop leukemia associated with DNA hypomethylation and oncogene activation. Lsh is a member of the S...

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Bibliografski detalji
Glavni autori: Fan, Tao, Schmidtmann, Anja, Xi, Sichuan, Briones, Victorino, Zhu, Heming, Suh, Hyung Chan, Gooya, John, Keller, Jonathan R., Xu, Hong, Roayaei, Jean, Anver, Miriam, Ruscetti, Sandra, Muegge, Kathrin
Format: Artigo
Jezik:Inglês
Izdano: 2008
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3113485/
https://ncbi.nlm.nih.gov/pubmed/18487951
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