Sustained Activation of Nuclear Erythroid 2-Related Factor 2/Antioxidant Response Element Signaling Promotes Reductive Stress in the Human Mutant Protein Aggregation Cardiomyopathy in Mice

Inheritable missense mutations in small molecular weight heat-shock proteins (HSP) with chaperone-like properties promote self-oligomerization, protein aggregation, and pathologic states such as hypertrophic cardiomyopathy in humans. We recently described that human mutant αB-crystallin (hR120GCryAB...

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Detalhes bibliográficos
Main Authors: Rajasekaran, Namakkal Soorappan, Varadharaj, Saradhadevi, Khanderao, Gayatri D., Davidson, Christopher J., Kannan, Sankaranarayanan, Firpo, Matthew A., Zweier, Jay L., Benjamin, Ivor J.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2011
Assuntos:
Original Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3113450/
https://ncbi.nlm.nih.gov/pubmed/21126175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2010.3587
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