Towards Al(3+)-Induced Manganese-Containing Superoxide Dismutase Inactivation and Conformational Changes: An Integrating Study with Docking Simulations

Superoxide dismutase (SOD, EC 1.15.1.1) plays an important antioxidant defense role in skins exposed to oxygen. We studied the inhibitory effects of Al(3+) on the activity and conformation of manganese-containing SOD (Mn-SOD). Mn-SOD was significantly inactivated by Al(3+) in a dose-dependent manner...

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Detalhes bibliográficos
Main Authors: Yang, Jiang-Liu, Yin, Shang-Jun, Si, Yue-Xiu, Lü, Zhi-Rong, Shao, Xiangrong, Park, Daeui, Chung, Hae Young, Zhou, Hai-Meng, Qian, Guo-Ying, Zhang, Zi-Ping
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE-Hindawi Access to Research 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3112498/
https://ncbi.nlm.nih.gov/pubmed/21687640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4061/2011/307464
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