High prevalence of dhfr triple mutant and correlation with high rates of sulphadoxine-pyrimethamine treatment failures in vivo in Gabonese children

BACKGROUND: Drug resistance contributes to the global malaria burden. Plasmodium falciparum dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) polymorphisms confer resistance to sulphadoxine-pyrimethamine (SP). METHODS: The study assessed the frequency of SP resistance-conferring pol...

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Main Authors: Mombo-Ngoma, Ghyslain, Oyakhirome, Sunny, Ord, Rosalynn, Gabor, Julian J, Greutélaers, Katja C, Profanter, Katharina, Greutélaers, Benedikt, Kurth, Florian, Lell, Bertrand, Kun, Jürgen FJ, Issifou, Saadou, Roper, Cally, Kremsner, Peter G, Grobusch, Martin P
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2011
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3112455/
https://ncbi.nlm.nih.gov/pubmed/21569596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2875-10-123
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