Safety and pharmacokinetics of recombinant human hepatocyte growth factor (rh-HGF) in patients with fulminant hepatitis: a phase I/II clinical trial, following preclinical studies to ensure safety

BACKGROUND: Hepatocyte growth factor (HGF) stimulates hepatocyte proliferation, and also acts as an anti-apoptotic factor. Therefore, HGF is a potential therapeutic agent for treatment of fatal liver diseases. We performed a translational medicine protocol with recombinant human HGF (rh-HGF), includ...

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Detalhes bibliográficos
Main Authors: Ido, Akio, Moriuchi, Akihiro, Numata, Masatsugu, Murayama, Toshinori, Teramukai, Satoshi, Marusawa, Hiroyuki, Yamaji, Naohisa, Setoyama, Hitoshi, Kim, Il-Deok, Chiba, Tsutomu, Higuchi, Shuji, Yokode, Masayuki, Fukushima, Masanori, Shimizu, Akira, Tsubouchi, Hirohito
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3112439/
https://ncbi.nlm.nih.gov/pubmed/21548996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-9-55
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