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Crystal structure of the ectodomain of Methuselah, a Drosophila G protein-coupled receptor associated with extended lifespan

The Drosophila mutant methuselah (mth) was identified from a screen for single gene mutations that extended average lifespan. Mth mutants have a 35% increase in average lifespan and increased resistance to several forms of stress, including heat, starvation, and oxidative damage. The protein affecte...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: West, Anthony P., Llamas, Lynda L., Snow, Peter M., Benzer, Seymour, Bjorkman, Pamela J.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2001
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC31123/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11274391/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.051625298
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