Hepatocyte-Targeted Expression by Integrase-Defective Lentiviral Vectors Induces Antigen-Specific Tolerance in Mice with Low Genotoxic Risk

Lentiviral vectors are attractive tools for liver-directed gene therapy because of their capacity for stable gene expression and the lack of preexisting immunity in most human subjects. However, the use of integrating vectors may raise some concerns about the potential risk of insertional mutagenesi...

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Bibliographic Details
Main Authors: Mátrai, Janka, Cantore, Alessio, Bartholomae, Cynthia C, Annoni, Andrea, Wang, Wei, Acosta-Sanchez, Abel, Samara-Kuko, Ermira, De Waele, Liesbeth, Ma, Ling, Genovese, Pietro, Damo, Martina, Arens, Anne, Goudy, Kevin, Nichols, Timothy C, von Kalle, Christof, Chuah, Marinee K L, Roncarolo, Maria Grazia, Schmidt, Manfred, VandenDriessche, Thierry, Naldini, Luigi
Format: Artigo
Language:Inglês
Published: Wiley Subscription Services, Inc., A Wiley Company 2011
Subjects:
Liver Biology/Pathobiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3112259/
https://ncbi.nlm.nih.gov/pubmed/21520180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.24230
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