Pro-apoptotic activity of α-bisabolol in preclinical models of primary human acute leukemia cells

BACKGROUND: We previously demonstrated that the plant-derived agent α-bisabolol enters cells via lipid rafts, binds to the pro-apoptotic Bcl-2 family protein BID, and may induce apoptosis. Here we studied the activity of α-bisabolol in acute leukemia cells. METHODS: We tested ex vivo blasts from 42...

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Hauptverfasser: Cavalieri, Elisabetta, Rigo, Antonella, Bonifacio, Massimiliano, de Prati, Alessandra Carcereri, Guardalben, Emanuele, Bergamini, Christian, Fato, Romana, Pizzolo, Giovanni, Suzuki, Hisanori, Vinante, Fabrizio
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2011
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3112094/
https://ncbi.nlm.nih.gov/pubmed/21510902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-9-45
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