Tetrahydrobiopterin depletion and NOS2 uncoupling contribute to heart failure-induced alterations in atrial electrophysiology

AIMS: Heart failure is a common antecedent to atrial fibrillation; both heart failure and atrial fibrillation are associated with increased myocardial oxidative stress. Chronic canine heart failure reduces atrial action potential duration and atrial refractoriness. We hypothesized that inducible nit...

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Hauptverfasser: Nishijima, Yoshinori, Sridhar, Arun, Bonilla, Ingrid, Velayutham, Murugesan, Khan, Mahmood, Terentyeva, Radmila, Li, Chun, Kuppusamy, Periannan, Elton, Terry S., Terentyev, Dmitry, Györke, Sandor, Zweier, Jay L., Cardounel, Arturo J., Carnes, Cynthia A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2011
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3112023/
https://ncbi.nlm.nih.gov/pubmed/21460065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvr087
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