Antineoplastic Agents. 590. The X-ray Crystal Structure of Dolastatin 16 and Syntheses of the Dolamethylleuine and Dolaphenvaline Units

Three advances necessary to bringing dolastatin 16 (1) into full-scale preclinical development as an anticancer drug have been accomplished. The X-ray crystal structure of dolastatin 16 has been solved, which allowed stereoselective syntheses of its two new amino acid units, dolamethylleuine (Dml) a...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Pettit, George R., Smith, Thomas H., Xu, Jun-Ping, Herald, Delbert L., Flahive, Erik J., Anderson, Collin R., Belcher, Paul E., Knight, John C.
Формат: Artigo
Язык:Inglês
Опубликовано: 2011
Предметы:
Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3111978/
https://ncbi.nlm.nih.gov/pubmed/21539315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/np100877h
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы