Inherited Variants in Mitochondrial Biogenesis Genes May Influence Epithelial Ovarian Cancer Risk

BACKGROUND: Mitochondria contribute to oxidative stress, a phenomenon implicated in ovarian carcinogenesis. We hypothesized that inherited variants in mitochondrial-related genes influence epithelial ovarian cancer (EOC) susceptibility. METHODS: Through a multi-center study of 1,815 Caucasian EOC ca...

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Autori principali: Permuth-Wey, Jennifer, Chen, Y. Ann, Tsai, Ya-Yu, Chen, Zhihua, Qu, Xiaotao, Lancaster, Johnathan M., Stockwell, Heather, Dagne, Getachew, Iversen, Edwin, Risch, Harvey, Barnholtz-Sloan, Jill, Cunningham, Julie M., Vierkant, Robert A., Fridley, Brooke L., Sutphen, Rebecca, McLaughlin, John, Narod, Steven A., Goode, Ellen L., Schildkraut, Joellen M., Fenstermacher, David, Phelan, Catherine M., Sellers, Thomas A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3111851/
https://ncbi.nlm.nih.gov/pubmed/21447778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1055-9965.EPI-10-1224
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