Biotransformation of 6-thioguanine in inflammatory bowel disease patients: a comparison of oral and intravenous administration of 6-thioguanine

BACKGROUND AND PURPOSE: Although 6-mercaptopurine and azathioprine are effective treatments in inflammatory bowel disease (IBD), many patients discontinue treatment because of side effects. 6-Thioguanine (6-TG) may be an alternative rescue therapy in these intolerant patients but the pharmacokinetic...

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Main Authors: Jharap, B, de Boer, NKH, Vos, RM, Smid, K, Zwiers, A, Peters, GJ, Mulder, CJJ, Wilhelm, AJ, van Bodegraven, AA
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Publishing Ltd 2011
Assuntos:
Research Papers
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3111675/
https://ncbi.nlm.nih.gov/pubmed/21323897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01265.x
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