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Cyclooxygenase 2-dependent and independent activation of Akt through casein kinase 2α contributes to human bladder cancer cell survival

BACKGROUND: Survival rate for patients presenting muscle invasive bladder cancer is very low, and useful therapeutic target has not been identified yet. In the present study, new COX2 downstream signals involved in urothelial carcinoma cell survival were investigated in vitro and in vivo. METHODS: C...

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Detalhes bibliográficos
Main Authors: Shimada, Keiji, Anai, Satoshi, Marco, Develasco A, Fujimoto, Kiyohide, Konishi, Noboru
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3111585/
https://ncbi.nlm.nih.gov/pubmed/21592330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2490-11-8
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