Electrostatic surface plasmon resonance: Direct electric field-induced hybridization and denaturation in monolayer nucleic acid films and label-free discrimination of base mismatches

We demonstrate that in situ optical surface plasmon resonance spectroscopy can be used to monitor hybridization kinetics for unlabeled DNA in tethered monolayer nucleic acid films on gold in the presence of an applied electrostatic field. The dc field can enhance or retard hybridization and can also...

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Detaylı Bibliyografya
Asıl Yazarlar: Heaton, Richard J., Peterson, Alexander W., Georgiadis, Rosina M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The National Academy of Sciences 2001
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC31115/
https://ncbi.nlm.nih.gov/pubmed/11259682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.071623998
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