Integrin activation and internalization on soft ECM as a mechanism of induction of stem cell differentiation by ECM elasticity

The mechanism by which ECM elasticity induces lineage specification of stem cells has not been clearly understood. Integrins are well-documented mechanosensors that are positioned at the beginning of the sensing pathway. By using an antibody specifically recognizing the active conformation of β1 int...

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Bibliographische Detailangaben
Hauptverfasser: Du, Jing, Chen, Xiaofei, Liang, Xudong, Zhang, Guangyao, Xu, Jia, He, Linrong, Zhan, Qingyuan, Feng, Xi-Qiao, Chien, Shu, Yang, Chun
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2011
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3111285/
https://ncbi.nlm.nih.gov/pubmed/21593411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1106467108
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