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Design of an in vivo cleavable disulfide linker in recombinant fusion proteins
In order to achieve an optimal biological activity and desired pharmacokinetic profiles, a dithiocyclopeptide linker was designed for in vivo release of protein domains from a recombinant fusion protein. This novel in vivo cleavable disulfide linker, based on a dithiocyclopeptide containing a thromb...
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| Main Authors: | , , , |
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| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
2010
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3111088/ https://ncbi.nlm.nih.gov/pubmed/20615204 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2144/000113450 |
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