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Abnormal trafficking and degradation of TLR4 underlie the elevated inflammatory response in cystic fibrosis
Morbidity and mortality in cystic fibrosis (CF) are due not only to abnormal epithelial cell function, but also to an abnormal immune response. We have shown previously that macrophages lacking CFTR, the gene mutated in CF, contribute significantly to the hyper-inflammatory response observed in CF....
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3111054/ https://ncbi.nlm.nih.gov/pubmed/21593379 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1100396 |
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